TL;DR: N-[4-[2-ethyl-4-(3-methylphenyl)-1,3-thiazol-5-yl]pyridin-2-yl]propanamide (CAS 365429-11-4) is a chemical compound with molecular formula C20H21N3OS and molecular weight 351.14053 g/mol, supplied by CoreyChem (Career Henan Chemical Co., Ltd.) with ISO-certified quality and global shipping.
N-[4-[2-ethyl-4-(3-methylphenyl)-1,3-thiazol-5-yl]-2-pyridinyl]propanamide
Also Known As: N-[4-[2-ethyl-4-(3-methylphenyl)-1,3-thiazol-5-yl]pyridin-2-yl]propanamide, N-[4-(2-Ethyl-4-m-tolyl-thiazol-5-yl)-pyridin-2-yl]-propionamide, N-[4-[2-ETHYL-4-(3-METHYLPHENYL)-1,3-THIAZOL-5-YL]-2-PYRIDYL]PROPIONAMIDE, N-{4-[2-ETHYL-4-(3-METHYLPHENYL)-1,3-THIAZOL-5-YL]PYRIDIN-2-YL}PROPANAMIDE
| Molecular Formula | C20H21N3OS |
| Molecular Weight | 351.14053 g/mol |
| XLogP | 4.4 |
| Topological Polar Surface Area (TPSA) | 83.1 Ų |
| Hydrogen Bond Donors | 1 |
| Hydrogen Bond Acceptors | 4 |
| Rotatable Bonds | 5 |
| Exact Mass | 351.14053 Da |
| Heavy Atoms | 25 |
| Complexity | 447.0 |
| SMILES | CCC1=NC(=C(S1)C2=CC(=NC=C2)NC(=O)CC)C3=CC=CC(=C3)C |
| InChIKey | QVEWLQUEUPMWAW-UHFFFAOYSA-N |
The XLogP value of 4.4 indicates that N-[4-[2-ethyl-4-(3-methylphenyl)-1,3-thiazol-5-yl]pyridin-2-yl]propanamide is lipophilic (fat-soluble), which may influence its absorption, distribution, and formulation strategy. The TPSA of 83.1 Ų falls within the moderate polarity range, balancing permeability and solubility for N-[4-[2-ethyl-4-(3-methylphenyl)-1,3-thiazol-5-yl]pyridin-2-yl]propanamide. Following Lipinski's Rule of Five, N-[4-[2-ethyl-4-(3-methylphenyl)-1,3-thiazol-5-yl]pyridin-2-yl]propanamide has 1 hydrogen bond donor(s) and 4 hydrogen bond acceptor(s), all within the drug-like range, suggesting favorable oral bioavailability potential.
The CAS number of N-[4-[2-ethyl-4-(3-methylphenyl)-1,3-thiazol-5-yl]pyridin-2-yl]propanamide is 365429-11-4.
The molecular formula of N-[4-[2-ethyl-4-(3-methylphenyl)-1,3-thiazol-5-yl]pyridin-2-yl]propanamide is C20H21N3OS.
The molecular weight of N-[4-[2-ethyl-4-(3-methylphenyl)-1,3-thiazol-5-yl]pyridin-2-yl]propanamide is 351.14053 g/mol.
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